TYLOPUR®

How to dissolve TYLOPUR® in water

Adding the TYLOPUR® powder directly into cold water can be challenging as lumps can easily be formed due to the incomplete wetting of the powder.

One method to avoid the lump formation is to take the advantage of the insolubility of hydroxyl propyl methyl cellulose in hot water (>70°C). After cooling down, the hydroxyl propyl methyl cellulose hydrates and dissolve fully. The hydration temperature depends on the substitution grade of hypromellose. For the TYLOPUR® types, this temperature should be below below 40°C and ideally less than 10°C. Thus a cooling bath is recommended for the preparation of the hypromellose solutions generally.

TYLOPUR® can be dissolved in organic solvents as well. Typical examples are a combination of ethanol and water or isopropanol and water.

TYLOPUR® low viscous grades as film coating material

TYLOPUR® 603 till 615 are ideal grades for the coating of oral solid dosage forms.

The tablet coating using hypromellose became popular because it is an easy method to protect fragile tablets and provide a smooth surface of the coated tablets. Another advantage for the extensive use of TYLOPUR® low viscous in coating applications is its solubility over the entire biological pH.

One of the main advantages using TYLOPUR® grades in tablet or pellet coating is the ability of hypromellose to form transparent and flexible films from aqueous solutions.

The most popular grades for tablet coating are the TYLOPUR® 605 and 606. In case of fragile tablets, TYLOPUR® 615 is recommended, whereas TYLOPUR® 603 can be used for pellet coating. Low viscosity hydroxyl propyl methyl cellulose grades are also one of the major products used for capsules coating or capsules banding. The aim of this application is to seal the gap existing between the two parts of the capsules in order to avoid any liquid penetration.

In order to easy differentiated from each other oral solid dosage forms having the same shape, pigments can be added to the hypromellose film solutions. In case that case, the film flexibility is decreased. Thus, we recommended to add plasticizers in the coating formulation. Furthermore, talc can be added to the coating formulation to optimize tablets slipping during the packaging or reduce the tackiness of tablets and pellets during the coating process.
 

TYLOPUR® used as capsule shell

Hydroxy propyl methyl cellulose films show as well interesting properties for the manufacturing of hard capsules. Thus, low viscosity TYLOPUR® is used to replace gelatine in this application.

The main advantages over gelatine are the better moisture stability as hypromellose is less moisture sensitive and its plant derived origin. The optimal solution for patients who follow a vegetarian or vegan diet.