Hypromellose acetate succinate is an enteric coating material
Enteric coating polymer and solid dispersion carrier invented by Shin-Etsu in the 1980s
Hypromellose acetate succinate (HPMCAS, NF, JP, EP) is an enteric coating material that can be used in aqueous or organic media.
Hypromellose is a non-toxic material which has been used in pharmaceutical, food, and cosmetic industries for many years. Based on hypromellose, acetyl and succinoyl groups are introduced to the hydroxyl groups of the backbone, and this constitutes Shin-Etsu AQOAT®, hypromellose acetate succinate (HPMCAS).
There are nine grades with different particle sizes (fine, medium, granular) and chemical substitution levels of acetyl and succinoyl groups to obtain an opening pH range from 5.5 to 6.5.
Shin-Etsu AQOAT® is the leading polymer in solid dispersion technology. It is suitable for spray-drying, hot melt extrusion, co-precipitation and other techniques. There are more than 14 approved products in the US using Shin-Etsu AQOAT® in solid dispersion.
Additionally, we designed our HME cleaner to support you with trouble free cleaning after the extrusion process. Please contact us for further information.
Aqueous fine particle coating with angled spray [A-044]
Aqueous formulation of Shin-Etsu AQOAT® (HPMCAS) containing an amino acid as stabilizer - comparison of formulation and process parameters on different coating equipment [A-055]
Comparative study of various coating methods with Shin-Etsu AQOAT® (HPMCAS) for pellets [A-060]
Comparison of mini-tablets enteric coating with Shin-Etsu AQOAT® (HPMCAS) using perforated pan or fluid bed coating equipment [A-056]
Concentration - viscosity curve of Shin-Etsu AQOAT® (HPMCAS) [A-064]
Direct compression of spray dried dispersion [A-072]
Dissolution behavior of coated fine particles by aqueous and solvent coating [A-045, H-013]
Dry Coating Technique of Pellets with Shin-Etsu AQOAT® using Centrifugal Granulator [A-075]
Effect of hot melt extrusion on the physicochemical properties of Shin-Etsu AQOAT® (HPMCAS) [A-017]
Effect of substitution of Shin-Etsu AQOAT® (HPMCAS) on dissolution profile of nifedipine solid dispersions (SD) prepared by Hot Melt Extrusion [A-032]
Enteric coating of hard gelatin capsules using Shin-Etsu AQOAT® (HPMCAS) [A-029]
Enteric coating of omeprazol granules using Shin-Etsu AQOAT® (HPMCAS) [A-031]
Enteric coating with Shin-Etsu AQOAT® (HPMCAS) by using water-ethanol solution [A-004]
Examples of aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) [A-003]
Impact of process parameters to solid dispersion particles [A-071]
Influence of alcohol on gastric resistance of Shin-Etsu AQOAT® (HPMCAS) [A-014]
IR spectrums of HPMCP and Shin-Etsu AQOAT® [H-017, A-054]
Mechanical properties of hot melt extruded amorphous solid dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-073]
Milling and downstream processing of hot melt extruded (HME) amorphous solid dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-067]
Minimum film formation temperature of Shin-Etsu AQOAT® (HPMCAS) (2) [A-047]
Minimum film formation temperature of Shin-Etsu AQOAT® (HPMCAS) [A-005]
Molecular weight of Shin-Etsu AQOAT® (HPMCAS) [A-007]
Nifedipine solid dispersion using Shin-Etsu AQOAT® - preparation by HME and downstream processing [A-051]
Optimized Spray Drying Formulation using Shin-Etsu AQOAT® (HPMCAS) Targeting a Drug Release in the Upper Small Intestine [A-074]
Partially neutralized coating technique using Shin-Etsu AQOAT® (HPMCAS) [A-037]
Scale-up of tablet enteric coating using the partially ammonia neutralized Shin-Etsu AQOAT® (HPMCAS) dispersion [A-068]
Solid dispersions (SD) using Shin-Etsu AQOAT® (HPMCAS) by holt melt extrusion [A-018]
Solubility of Shin-Etsu AQOAT® (HPMCAS) in alkali solutions for cleaning media after coating operations [A-021]
Solubility of Shin-Etsu AQOAT® (HPMCAS) in mixed organic solvents [A-035]
Solution preparation of HPMCP and Shin-Etsu AQOAT® (HPMCAS) [H-019, A-058]
Stability of Shin-Etsu AQOAT® (HPMCAS) at high temperatures [A-010]
Taste masking coating for quinine tablets [A-061]
Taste masking coating using Shin-Etsu AQOAT® (HPMCAS) and PHARMACOAT® with controlled release [A-063, P-018]
Triacetin as an alternative plasticizer for aqueous dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-057]
Aqueous fine particle coating with angled spray [A-044]
Aqueous formulation of Shin-Etsu AQOAT® (HPMCAS) containing an amino acid as stabilizer - comparison of formulation and process parameters on different coating equipment [A-055]
Comparative study of various coating methods with Shin-Etsu AQOAT® (HPMCAS) for pellets [A-060]
Comparison of mini-tablets enteric coating with Shin-Etsu AQOAT® (HPMCAS) using perforated pan or fluid bed coating equipment [A-056]
Concentration - viscosity curve of Shin-Etsu AQOAT® (HPMCAS) [A-064]
Direct compression of spray dried dispersion [A-072]
Dissolution behavior of coated fine particles by aqueous and solvent coating [A-045, H-013]
Dry Coating Technique of Pellets with Shin-Etsu AQOAT® using Centrifugal Granulator [A-075]
Effect of hot melt extrusion on the physicochemical properties of Shin-Etsu AQOAT® (HPMCAS) [A-017]
Effect of substitution of Shin-Etsu AQOAT® (HPMCAS) on dissolution profile of nifedipine solid dispersions (SD) prepared by Hot Melt Extrusion [A-032]
Enteric coating of hard gelatin capsules using Shin-Etsu AQOAT® (HPMCAS) [A-029]
Enteric coating of omeprazol granules using Shin-Etsu AQOAT® (HPMCAS) [A-031]
Enteric coating with Shin-Etsu AQOAT® (HPMCAS) by using water-ethanol solution [A-004]
Examples of aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) [A-003]
Impact of process parameters to solid dispersion particles [A-071]
Influence of alcohol on gastric resistance of Shin-Etsu AQOAT® (HPMCAS) [A-014]
IR spectrums of HPMCP and Shin-Etsu AQOAT® [H-017, A-054]
Mechanical properties of hot melt extruded amorphous solid dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-073]
Milling and downstream processing of hot melt extruded (HME) amorphous solid dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-067]
Minimum film formation temperature of Shin-Etsu AQOAT® (HPMCAS) (2) [A-047]
Minimum film formation temperature of Shin-Etsu AQOAT® (HPMCAS) [A-005]
Molecular weight of Shin-Etsu AQOAT® (HPMCAS) [A-007]
Nifedipine solid dispersion using Shin-Etsu AQOAT® - preparation by HME and downstream processing [A-051]
Optimized Spray Drying Formulation using Shin-Etsu AQOAT® (HPMCAS) Targeting a Drug Release in the Upper Small Intestine [A-074]
Partially neutralized coating technique using Shin-Etsu AQOAT® (HPMCAS) [A-037]
Scale-up of tablet enteric coating using the partially ammonia neutralized Shin-Etsu AQOAT® (HPMCAS) dispersion [A-068]
Solid dispersions (SD) using Shin-Etsu AQOAT® (HPMCAS) by holt melt extrusion [A-018]
Solubility of Shin-Etsu AQOAT® (HPMCAS) in alkali solutions for cleaning media after coating operations [A-021]
Solubility of Shin-Etsu AQOAT® (HPMCAS) in mixed organic solvents [A-035]
Solution preparation of HPMCP and Shin-Etsu AQOAT® (HPMCAS) [H-019, A-058]
Stability of Shin-Etsu AQOAT® (HPMCAS) at high temperatures [A-010]
Taste masking coating for quinine tablets [A-061]
Taste masking coating using Shin-Etsu AQOAT® (HPMCAS) and PHARMACOAT® with controlled release [A-063, P-018]
Triacetin as an alternative plasticizer for aqueous dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-057]
Aqueous fine particle coating with angled spray [A-044]
Aqueous formulation of Shin-Etsu AQOAT® (HPMCAS) containing an amino acid as stabilizer - comparison of formulation and process parameters on different coating equipment [A-055]
Comparative study of various coating methods with Shin-Etsu AQOAT® (HPMCAS) for pellets [A-060]
Comparison of mini-tablets enteric coating with Shin-Etsu AQOAT® (HPMCAS) using perforated pan or fluid bed coating equipment [A-056]
Concentration - viscosity curve of Shin-Etsu AQOAT® (HPMCAS) [A-064]
Direct compression of spray dried dispersion [A-072]
Dissolution behavior of coated fine particles by aqueous and solvent coating [A-045, H-013]
Dry Coating Technique of Pellets with Shin-Etsu AQOAT® using Centrifugal Granulator [A-075]
Effect of hot melt extrusion on the physicochemical properties of Shin-Etsu AQOAT® (HPMCAS) [A-017]
Effect of substitution of Shin-Etsu AQOAT® (HPMCAS) on dissolution profile of nifedipine solid dispersions (SD) prepared by Hot Melt Extrusion [A-032]
Enteric coating of hard gelatin capsules using Shin-Etsu AQOAT® (HPMCAS) [A-029]
Enteric coating of omeprazol granules using Shin-Etsu AQOAT® (HPMCAS) [A-031]
Enteric coating with Shin-Etsu AQOAT® (HPMCAS) by using water-ethanol solution [A-004]
Examples of aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) [A-003]
Impact of process parameters to solid dispersion particles [A-071]
Influence of alcohol on gastric resistance of Shin-Etsu AQOAT® (HPMCAS) [A-014]
IR spectrums of HPMCP and Shin-Etsu AQOAT® [H-017, A-054]
Mechanical properties of hot melt extruded amorphous solid dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-073]
Milling and downstream processing of hot melt extruded (HME) amorphous solid dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-067]
Minimum film formation temperature of Shin-Etsu AQOAT® (HPMCAS) (2) [A-047]
Minimum film formation temperature of Shin-Etsu AQOAT® (HPMCAS) [A-005]
Molecular weight of Shin-Etsu AQOAT® (HPMCAS) [A-007]
Nifedipine solid dispersion using Shin-Etsu AQOAT® - preparation by HME and downstream processing [A-051]
Optimized Spray Drying Formulation using Shin-Etsu AQOAT® (HPMCAS) Targeting a Drug Release in the Upper Small Intestine [A-074]
Partially neutralized coating technique using Shin-Etsu AQOAT® (HPMCAS) [A-037]
Scale-up of tablet enteric coating using the partially ammonia neutralized Shin-Etsu AQOAT® (HPMCAS) dispersion [A-068]
Solid dispersions (SD) using Shin-Etsu AQOAT® (HPMCAS) by holt melt extrusion [A-018]
Solubility of Shin-Etsu AQOAT® (HPMCAS) in alkali solutions for cleaning media after coating operations [A-021]
Solubility of Shin-Etsu AQOAT® (HPMCAS) in mixed organic solvents [A-035]
Solution preparation of HPMCP and Shin-Etsu AQOAT® (HPMCAS) [H-019, A-058]
Stability of Shin-Etsu AQOAT® (HPMCAS) at high temperatures [A-010]
Taste masking coating for quinine tablets [A-061]
Taste masking coating using Shin-Etsu AQOAT® (HPMCAS) and PHARMACOAT® with controlled release [A-063, P-018]
Triacetin as an alternative plasticizer for aqueous dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-057]
3D printing tablets with Shin-Etsu AQOAT® (HPMCAS) [A-069]
Application of Shin-Etsu AQOAT® (HPMCAS) as a carrier in solid dispersion [A-028]
Application of Shin-Etsu AQOAT® (HPMCAS) in extended release (ER) matrix tablet formulation [A-070]
Aqueous based enteric formulation of Shin-Etsu AQOAT® (HPMCAS) containing amino acid as a stabilizer [A-049]
Aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) (Coating parameters of a tablet batch size 5-100kg) [A-002]
Aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) (Preparation of coating dispersion) [A-001]
Aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) (Using a small tabletop coating machine we coated tablet batch size of 300g) [A-006]
Aqueous enteric coating for lansoprazole using Shin-Etsu AQOAT® (HPMCAS) [A-059]
Aqueous enteric coating for soft gelatin capsule using Shin-Etsu AQOAT® (HPMCAS) [A-043]
Aqueous enteric coating for soft gelatin capsule with Shin-Etsu AQOAT® (HPMCAS) [A-062]
Aqueous enteric coating using Shin-Etsu AQOAT® (HPMCAS) for Mini-Tablets [A-053]
Aqueous enteric coating with Shin-Etsu AQOAT® (HPMCAS): ammonia-neutralized method - part 1: solution and film properties [A-008]
Aqueous enteric coating with Shin-Etsu AQOAT® (HPMCAS): ammonia-neutralized method - part 2: examples of coating applications [A-012]
Aqueous enteric coating with Shin-Etsu AQOAT® (HPMCAS): ammonia-neutralized method - part 3: stability of the coated preparations [A-013]
Aqueous fine particle coating with angled spray [A-044]
Aqueous formulation of Shin-Etsu AQOAT® (HPMCAS) containing an amino acid as stabilizer - comparison of formulation and process parameters on different coating equipment [A-055]
Comparative study of various coating methods with Shin-Etsu AQOAT® (HPMCAS) for pellets [A-060]
Comparison of mini-tablets enteric coating with Shin-Etsu AQOAT® (HPMCAS) using perforated pan or fluid bed coating equipment [A-056]
Concentration - viscosity curve of Shin-Etsu AQOAT® (HPMCAS) [A-064]
Direct compression of spray dried dispersion [A-072]
Dissolution behavior of coated fine particles by aqueous and solvent coating [A-045, H-013]
Effect of hot melt extrusion on the physicochemical properties of Shin-Etsu AQOAT® (HPMCAS) [A-017]
Effect of substitution of Shin-Etsu AQOAT® (HPMCAS) on dissolution profile of nifedipine solid dispersions (SD) prepared by Hot Melt Extrusion [A-032]
Enteric coating of hard gelatin capsules using Shin-Etsu AQOAT® (HPMCAS) [A-029]
Enteric coating of omeprazol granules using Shin-Etsu AQOAT® (HPMCAS) [A-031]
Enteric coating with Shin-Etsu AQOAT® (HPMCAS) by using water-ethanol solution [A-004]
Examples of aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) [A-003]
Impact of process parameters to solid dispersion particles [A-071]
Influence of alcohol on gastric resistance of Shin-Etsu AQOAT® (HPMCAS) [A-014]
IR spectrums of HPMCP and Shin-Etsu AQOAT® [H-017, A-054]
Mechanical properties of hot melt extruded amorphous solid dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-073]
Milling and downstream processing of hot melt extruded (HME) amorphous solid dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-067]
Minimum film formation temperature of Shin-Etsu AQOAT® (HPMCAS) (2) [A-047]
Minimum film formation temperature of Shin-Etsu AQOAT® (HPMCAS) [A-005]
Molecular weight of Shin-Etsu AQOAT® (HPMCAS) [A-007]
Nifedipine solid dispersion using Shin-Etsu AQOAT® - preparation by HME and downstream processing [A-051]
Partially neutralized coating technique using Shin-Etsu AQOAT® (HPMCAS) [A-037]
Scale-up of tablet enteric coating using the partially ammonia neutralized Shin-Etsu AQOAT® (HPMCAS) dispersion [A-068]
Solid dispersions (SD) using Shin-Etsu AQOAT® (HPMCAS) by holt melt extrusion [A-018]
Solubility of Shin-Etsu AQOAT® (HPMCAS) in alkali solutions for cleaning media after coating operations [A-021]
Solubility of Shin-Etsu AQOAT® (HPMCAS) in mixed organic solvents [A-035]
Solution preparation of HPMCP and Shin-Etsu AQOAT® (HPMCAS) [H-019, A-058]
Stability of Shin-Etsu AQOAT® (HPMCAS) at high temperatures [A-010]
Taste masking coating for quinine tablets [A-061]
Taste masking coating using Shin-Etsu AQOAT® (HPMCAS) and PHARMACOAT® with controlled release [A-063, P-018]
Triacetin as an alternative plasticizer for aqueous dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-057]
3D printing tablets with Shin-Etsu AQOAT® (HPMCAS) [A-069]
Application of Shin-Etsu AQOAT® (HPMCAS) as a carrier in solid dispersion [A-028]
Application of Shin-Etsu AQOAT® (HPMCAS) in extended release (ER) matrix tablet formulation [A-070]
Aqueous based enteric formulation of Shin-Etsu AQOAT® (HPMCAS) containing amino acid as a stabilizer [A-049]
Aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) (Coating parameters of a tablet batch size 5-100kg) [A-002]
Aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) (Preparation of coating dispersion) [A-001]
Aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) (Using a small tabletop coating machine we coated tablet batch size of 300g) [A-006]
Aqueous enteric coating for lansoprazole using Shin-Etsu AQOAT® (HPMCAS) [A-059]
Aqueous enteric coating for soft gelatin capsule using Shin-Etsu AQOAT® (HPMCAS) [A-043]
Aqueous enteric coating for soft gelatin capsule with Shin-Etsu AQOAT® (HPMCAS) [A-062]
Aqueous enteric coating using Shin-Etsu AQOAT® (HPMCAS) for Mini-Tablets [A-053]
Aqueous enteric coating with Shin-Etsu AQOAT® (HPMCAS): ammonia-neutralized method - part 1: solution and film properties [A-008]
Aqueous enteric coating with Shin-Etsu AQOAT® (HPMCAS): ammonia-neutralized method - part 2: examples of coating applications [A-012]
Aqueous enteric coating with Shin-Etsu AQOAT® (HPMCAS): ammonia-neutralized method - part 3: stability of the coated preparations [A-013]
Aqueous fine particle coating with angled spray [A-044]
Aqueous formulation of Shin-Etsu AQOAT® (HPMCAS) containing an amino acid as stabilizer - comparison of formulation and process parameters on different coating equipment [A-055]
Comparative study of various coating methods with Shin-Etsu AQOAT® (HPMCAS) for pellets [A-060]
Comparison of mini-tablets enteric coating with Shin-Etsu AQOAT® (HPMCAS) using perforated pan or fluid bed coating equipment [A-056]
Concentration - viscosity curve of Shin-Etsu AQOAT® (HPMCAS) [A-064]
Direct compression of spray dried dispersion [A-072]
Dissolution behavior of coated fine particles by aqueous and solvent coating [A-045, H-013]
Effect of hot melt extrusion on the physicochemical properties of Shin-Etsu AQOAT® (HPMCAS) [A-017]
Effect of substitution of Shin-Etsu AQOAT® (HPMCAS) on dissolution profile of nifedipine solid dispersions (SD) prepared by Hot Melt Extrusion [A-032]
Enteric coating of hard gelatin capsules using Shin-Etsu AQOAT® (HPMCAS) [A-029]
Enteric coating of omeprazol granules using Shin-Etsu AQOAT® (HPMCAS) [A-031]
Enteric coating with Shin-Etsu AQOAT® (HPMCAS) by using water-ethanol solution [A-004]
Examples of aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) [A-003]
Impact of process parameters to solid dispersion particles [A-071]
Influence of alcohol on gastric resistance of Shin-Etsu AQOAT® (HPMCAS) [A-014]
IR spectrums of HPMCP and Shin-Etsu AQOAT® [H-017, A-054]
Mechanical properties of hot melt extruded amorphous solid dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-073]
Milling and downstream processing of hot melt extruded (HME) amorphous solid dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-067]
Minimum film formation temperature of Shin-Etsu AQOAT® (HPMCAS) (2) [A-047]
Minimum film formation temperature of Shin-Etsu AQOAT® (HPMCAS) [A-005]
Molecular weight of Shin-Etsu AQOAT® (HPMCAS) [A-007]
Nifedipine solid dispersion using Shin-Etsu AQOAT® - preparation by HME and downstream processing [A-051]
Partially neutralized coating technique using Shin-Etsu AQOAT® (HPMCAS) [A-037]
Scale-up of tablet enteric coating using the partially ammonia neutralized Shin-Etsu AQOAT® (HPMCAS) dispersion [A-068]
Solid dispersions (SD) using Shin-Etsu AQOAT® (HPMCAS) by holt melt extrusion [A-018]
Solubility of Shin-Etsu AQOAT® (HPMCAS) in alkali solutions for cleaning media after coating operations [A-021]
Solubility of Shin-Etsu AQOAT® (HPMCAS) in mixed organic solvents [A-035]
Solution preparation of HPMCP and Shin-Etsu AQOAT® (HPMCAS) [H-019, A-058]
Stability of Shin-Etsu AQOAT® (HPMCAS) at high temperatures [A-010]
Taste masking coating for quinine tablets [A-061]
Taste masking coating using Shin-Etsu AQOAT® (HPMCAS) and PHARMACOAT® with controlled release [A-063, P-018]
Triacetin as an alternative plasticizer for aqueous dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-057]
3D printing tablets with Shin-Etsu AQOAT® (HPMCAS) [A-069]
Application of Shin-Etsu AQOAT® (HPMCAS) as a carrier in solid dispersion [A-028]
Application of Shin-Etsu AQOAT® (HPMCAS) in extended release (ER) matrix tablet formulation [A-070]
Aqueous based enteric formulation of Shin-Etsu AQOAT® (HPMCAS) containing amino acid as a stabilizer [A-049]
Aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) (Coating parameters of a tablet batch size 5-100kg) [A-002]
Aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) (Preparation of coating dispersion) [A-001]
Aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) (Using a small tabletop coating machine we coated tablet batch size of 300g) [A-006]
Aqueous enteric coating for lansoprazole using Shin-Etsu AQOAT® (HPMCAS) [A-059]
Aqueous enteric coating for soft gelatin capsule using Shin-Etsu AQOAT® (HPMCAS) [A-043]
Aqueous enteric coating for soft gelatin capsule with Shin-Etsu AQOAT® (HPMCAS) [A-062]
Aqueous enteric coating using Shin-Etsu AQOAT® (HPMCAS) for Mini-Tablets [A-053]
Aqueous enteric coating with Shin-Etsu AQOAT® (HPMCAS): ammonia-neutralized method - part 1: solution and film properties [A-008]
Aqueous enteric coating with Shin-Etsu AQOAT® (HPMCAS): ammonia-neutralized method - part 2: examples of coating applications [A-012]
Aqueous enteric coating with Shin-Etsu AQOAT® (HPMCAS): ammonia-neutralized method - part 3: stability of the coated preparations [A-013]
Aqueous fine particle coating with angled spray [A-044]
Aqueous formulation of Shin-Etsu AQOAT® (HPMCAS) containing an amino acid as stabilizer - comparison of formulation and process parameters on different coating equipment [A-055]
Comparative study of various coating methods with Shin-Etsu AQOAT® (HPMCAS) for pellets [A-060]
Comparison of mini-tablets enteric coating with Shin-Etsu AQOAT® (HPMCAS) using perforated pan or fluid bed coating equipment [A-056]
Concentration - viscosity curve of Shin-Etsu AQOAT® (HPMCAS) [A-064]
Direct compression of spray dried dispersion [A-072]
Dissolution behavior of coated fine particles by aqueous and solvent coating [A-045, H-013]
Effect of hot melt extrusion on the physicochemical properties of Shin-Etsu AQOAT® (HPMCAS) [A-017]
Effect of substitution of Shin-Etsu AQOAT® (HPMCAS) on dissolution profile of nifedipine solid dispersions (SD) prepared by Hot Melt Extrusion [A-032]
Enteric coating of hard gelatin capsules using Shin-Etsu AQOAT® (HPMCAS) [A-029]
Enteric coating of omeprazol granules using Shin-Etsu AQOAT® (HPMCAS) [A-031]
Enteric coating with Shin-Etsu AQOAT® (HPMCAS) by using water-ethanol solution [A-004]
Examples of aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) [A-003]
Impact of process parameters to solid dispersion particles [A-071]
Influence of alcohol on gastric resistance of Shin-Etsu AQOAT® (HPMCAS) [A-014]
IR spectrums of HPMCP and Shin-Etsu AQOAT® [H-017, A-054]
Mechanical properties of hot melt extruded amorphous solid dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-073]
Milling and downstream processing of hot melt extruded (HME) amorphous solid dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-067]
Minimum film formation temperature of Shin-Etsu AQOAT® (HPMCAS) (2) [A-047]
Minimum film formation temperature of Shin-Etsu AQOAT® (HPMCAS) [A-005]
Molecular weight of Shin-Etsu AQOAT® (HPMCAS) [A-007]
Nifedipine solid dispersion using Shin-Etsu AQOAT® - preparation by HME and downstream processing [A-051]
Partially neutralized coating technique using Shin-Etsu AQOAT® (HPMCAS) [A-037]
Scale-up of tablet enteric coating using the partially ammonia neutralized Shin-Etsu AQOAT® (HPMCAS) dispersion [A-068]
Solid dispersions (SD) using Shin-Etsu AQOAT® (HPMCAS) by holt melt extrusion [A-018]
Solubility of Shin-Etsu AQOAT® (HPMCAS) in alkali solutions for cleaning media after coating operations [A-021]
Solubility of Shin-Etsu AQOAT® (HPMCAS) in mixed organic solvents [A-035]
Solution preparation of HPMCP and Shin-Etsu AQOAT® (HPMCAS) [H-019, A-058]
Stability of Shin-Etsu AQOAT® (HPMCAS) at high temperatures [A-010]
Taste masking coating for quinine tablets [A-061]
Taste masking coating using Shin-Etsu AQOAT® (HPMCAS) and PHARMACOAT® with controlled release [A-063, P-018]
Triacetin as an alternative plasticizer for aqueous dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-057]
3D printing tablets with Shin-Etsu AQOAT® (HPMCAS) [A-069]
Application of Shin-Etsu AQOAT® (HPMCAS) as a carrier in solid dispersion [A-028]
Application of Shin-Etsu AQOAT® (HPMCAS) in extended release (ER) matrix tablet formulation [A-070]
Aqueous based enteric formulation of Shin-Etsu AQOAT® (HPMCAS) containing amino acid as a stabilizer [A-049]
Aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) (Coating parameters of a tablet batch size 5-100kg) [A-002]
Aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) (Preparation of coating dispersion) [A-001]
Aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) (Using a small tabletop coating machine we coated tablet batch size of 300g) [A-006]
Aqueous enteric coating for lansoprazole using Shin-Etsu AQOAT® (HPMCAS) [A-059]
Aqueous enteric coating for soft gelatin capsule using Shin-Etsu AQOAT® (HPMCAS) [A-043]
Aqueous enteric coating for soft gelatin capsule with Shin-Etsu AQOAT® (HPMCAS) [A-062]
Aqueous enteric coating using Shin-Etsu AQOAT® (HPMCAS) for Mini-Tablets [A-053]
Aqueous enteric coating with Shin-Etsu AQOAT® (HPMCAS): ammonia-neutralized method - part 1: solution and film properties [A-008]
Aqueous enteric coating with Shin-Etsu AQOAT® (HPMCAS): ammonia-neutralized method - part 2: examples of coating applications [A-012]
Aqueous enteric coating with Shin-Etsu AQOAT® (HPMCAS): ammonia-neutralized method - part 3: stability of the coated preparations [A-013]
Aqueous fine particle coating with angled spray [A-044]
Aqueous formulation of Shin-Etsu AQOAT® (HPMCAS) containing an amino acid as stabilizer - comparison of formulation and process parameters on different coating equipment [A-055]
Comparative study of various coating methods with Shin-Etsu AQOAT® (HPMCAS) for pellets [A-060]
Comparison of mini-tablets enteric coating with Shin-Etsu AQOAT® (HPMCAS) using perforated pan or fluid bed coating equipment [A-056]
Concentration - viscosity curve of Shin-Etsu AQOAT® (HPMCAS) [A-064]
Direct compression of spray dried dispersion [A-072]
Dissolution behavior of coated fine particles by aqueous and solvent coating [A-045, H-013]
Effect of hot melt extrusion on the physicochemical properties of Shin-Etsu AQOAT® (HPMCAS) [A-017]
Effect of substitution of Shin-Etsu AQOAT® (HPMCAS) on dissolution profile of nifedipine solid dispersions (SD) prepared by Hot Melt Extrusion [A-032]
Enteric coating of hard gelatin capsules using Shin-Etsu AQOAT® (HPMCAS) [A-029]
Enteric coating of omeprazol granules using Shin-Etsu AQOAT® (HPMCAS) [A-031]
Enteric coating with Shin-Etsu AQOAT® (HPMCAS) by using water-ethanol solution [A-004]
Examples of aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) [A-003]
Impact of process parameters to solid dispersion particles [A-071]
Influence of alcohol on gastric resistance of Shin-Etsu AQOAT® (HPMCAS) [A-014]
IR spectrums of HPMCP and Shin-Etsu AQOAT® [H-017, A-054]
Mechanical properties of hot melt extruded amorphous solid dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-073]
Milling and downstream processing of hot melt extruded (HME) amorphous solid dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-067]
Minimum film formation temperature of Shin-Etsu AQOAT® (HPMCAS) (2) [A-047]
Minimum film formation temperature of Shin-Etsu AQOAT® (HPMCAS) [A-005]
Molecular weight of Shin-Etsu AQOAT® (HPMCAS) [A-007]
Nifedipine solid dispersion using Shin-Etsu AQOAT® - preparation by HME and downstream processing [A-051]
Partially neutralized coating technique using Shin-Etsu AQOAT® (HPMCAS) [A-037]
Scale-up of tablet enteric coating using the partially ammonia neutralized Shin-Etsu AQOAT® (HPMCAS) dispersion [A-068]
Solid dispersions (SD) using Shin-Etsu AQOAT® (HPMCAS) by holt melt extrusion [A-018]
Solubility of Shin-Etsu AQOAT® (HPMCAS) in alkali solutions for cleaning media after coating operations [A-021]
Solubility of Shin-Etsu AQOAT® (HPMCAS) in mixed organic solvents [A-035]
Solution preparation of HPMCP and Shin-Etsu AQOAT® (HPMCAS) [H-019, A-058]
Stability of Shin-Etsu AQOAT® (HPMCAS) at high temperatures [A-010]
Taste masking coating for quinine tablets [A-061]
Taste masking coating using Shin-Etsu AQOAT® (HPMCAS) and PHARMACOAT® with controlled release [A-063, P-018]
Triacetin as an alternative plasticizer for aqueous dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-057]
3D printing tablets with Shin-Etsu AQOAT® (HPMCAS) [A-069]
Application of Shin-Etsu AQOAT® (HPMCAS) as a carrier in solid dispersion [A-028]
Application of Shin-Etsu AQOAT® (HPMCAS) in extended release (ER) matrix tablet formulation [A-070]
Aqueous based enteric formulation of Shin-Etsu AQOAT® (HPMCAS) containing amino acid as a stabilizer [A-049]
Aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) (Coating parameters of a tablet batch size 5-100kg) [A-002]
Aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) (Preparation of coating dispersion) [A-001]
Aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) (Using a small tabletop coating machine we coated tablet batch size of 300g) [A-006]
Aqueous enteric coating for lansoprazole using Shin-Etsu AQOAT® (HPMCAS) [A-059]
Aqueous enteric coating for soft gelatin capsule using Shin-Etsu AQOAT® (HPMCAS) [A-043]
Aqueous enteric coating for soft gelatin capsule with Shin-Etsu AQOAT® (HPMCAS) [A-062]
Aqueous enteric coating using Shin-Etsu AQOAT® (HPMCAS) for Mini-Tablets [A-053]
Aqueous enteric coating with Shin-Etsu AQOAT® (HPMCAS): ammonia-neutralized method - part 1: solution and film properties [A-008]
Aqueous enteric coating with Shin-Etsu AQOAT® (HPMCAS): ammonia-neutralized method - part 2: examples of coating applications [A-012]
Aqueous enteric coating with Shin-Etsu AQOAT® (HPMCAS): ammonia-neutralized method - part 3: stability of the coated preparations [A-013]
Aqueous fine particle coating with angled spray [A-044]
Aqueous formulation of Shin-Etsu AQOAT® (HPMCAS) containing an amino acid as stabilizer - comparison of formulation and process parameters on different coating equipment [A-055]
Comparative study of various coating methods with Shin-Etsu AQOAT® (HPMCAS) for pellets [A-060]
Comparison of mini-tablets enteric coating with Shin-Etsu AQOAT® (HPMCAS) using perforated pan or fluid bed coating equipment [A-056]
Concentration - viscosity curve of Shin-Etsu AQOAT® (HPMCAS) [A-064]
Direct compression of spray dried dispersion [A-072]
Dissolution behavior of coated fine particles by aqueous and solvent coating [A-045, H-013]
Effect of hot melt extrusion on the physicochemical properties of Shin-Etsu AQOAT® (HPMCAS) [A-017]
Effect of substitution of Shin-Etsu AQOAT® (HPMCAS) on dissolution profile of nifedipine solid dispersions (SD) prepared by Hot Melt Extrusion [A-032]
Enteric coating of hard gelatin capsules using Shin-Etsu AQOAT® (HPMCAS) [A-029]
Enteric coating of omeprazol granules using Shin-Etsu AQOAT® (HPMCAS) [A-031]
Enteric coating with Shin-Etsu AQOAT® (HPMCAS) by using water-ethanol solution [A-004]
Examples of aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) [A-003]
Impact of process parameters to solid dispersion particles [A-071]
Influence of alcohol on gastric resistance of Shin-Etsu AQOAT® (HPMCAS) [A-014]
IR spectrums of HPMCP and Shin-Etsu AQOAT® [H-017, A-054]
Mechanical properties of hot melt extruded amorphous solid dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-073]
Milling and downstream processing of hot melt extruded (HME) amorphous solid dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-067]
Minimum film formation temperature of Shin-Etsu AQOAT® (HPMCAS) (2) [A-047]
Minimum film formation temperature of Shin-Etsu AQOAT® (HPMCAS) [A-005]
Molecular weight of Shin-Etsu AQOAT® (HPMCAS) [A-007]
Nifedipine solid dispersion using Shin-Etsu AQOAT® - preparation by HME and downstream processing [A-051]
Partially neutralized coating technique using Shin-Etsu AQOAT® (HPMCAS) [A-037]
Scale-up of tablet enteric coating using the partially ammonia neutralized Shin-Etsu AQOAT® (HPMCAS) dispersion [A-068]
Solid dispersions (SD) using Shin-Etsu AQOAT® (HPMCAS) by holt melt extrusion [A-018]
Solubility of Shin-Etsu AQOAT® (HPMCAS) in alkali solutions for cleaning media after coating operations [A-021]
Solubility of Shin-Etsu AQOAT® (HPMCAS) in mixed organic solvents [A-035]
Solution preparation of HPMCP and Shin-Etsu AQOAT® (HPMCAS) [H-019, A-058]
Stability of Shin-Etsu AQOAT® (HPMCAS) at high temperatures [A-010]
Taste masking coating for quinine tablets [A-061]
Taste masking coating using Shin-Etsu AQOAT® (HPMCAS) and PHARMACOAT® with controlled release [A-063, P-018]
Triacetin as an alternative plasticizer for aqueous dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-057]
3D printing tablets with Shin-Etsu AQOAT® (HPMCAS) [A-069]
Application of Shin-Etsu AQOAT® (HPMCAS) as a carrier in solid dispersion [A-028]
Application of Shin-Etsu AQOAT® (HPMCAS) in extended release (ER) matrix tablet formulation [A-070]
Aqueous based enteric formulation of Shin-Etsu AQOAT® (HPMCAS) containing amino acid as a stabilizer [A-049]
Aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) (Coating parameters of a tablet batch size 5-100kg) [A-002]
Aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) (Preparation of coating dispersion) [A-001]
Aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) (Using a small tabletop coating machine we coated tablet batch size of 300g) [A-006]
Aqueous enteric coating for lansoprazole using Shin-Etsu AQOAT® (HPMCAS) [A-059]
Aqueous enteric coating for soft gelatin capsule using Shin-Etsu AQOAT® (HPMCAS) [A-043]
Aqueous enteric coating for soft gelatin capsule with Shin-Etsu AQOAT® (HPMCAS) [A-062]
Aqueous enteric coating using Shin-Etsu AQOAT® (HPMCAS) for Mini-Tablets [A-053]
Aqueous enteric coating with Shin-Etsu AQOAT® (HPMCAS): ammonia-neutralized method - part 1: solution and film properties [A-008]
Aqueous enteric coating with Shin-Etsu AQOAT® (HPMCAS): ammonia-neutralized method - part 2: examples of coating applications [A-012]
Aqueous enteric coating with Shin-Etsu AQOAT® (HPMCAS): ammonia-neutralized method - part 3: stability of the coated preparations [A-013]
Aqueous fine particle coating with angled spray [A-044]
Aqueous formulation of Shin-Etsu AQOAT® (HPMCAS) containing an amino acid as stabilizer - comparison of formulation and process parameters on different coating equipment [A-055]
Comparative study of various coating methods with Shin-Etsu AQOAT® (HPMCAS) for pellets [A-060]
Comparison of mini-tablets enteric coating with Shin-Etsu AQOAT® (HPMCAS) using perforated pan or fluid bed coating equipment [A-056]
Concentration - viscosity curve of Shin-Etsu AQOAT® (HPMCAS) [A-064]
Direct compression of spray dried dispersion [A-072]
Dissolution behavior of coated fine particles by aqueous and solvent coating [A-045, H-013]
Effect of hot melt extrusion on the physicochemical properties of Shin-Etsu AQOAT® (HPMCAS) [A-017]
Effect of substitution of Shin-Etsu AQOAT® (HPMCAS) on dissolution profile of nifedipine solid dispersions (SD) prepared by Hot Melt Extrusion [A-032]
Enteric coating of hard gelatin capsules using Shin-Etsu AQOAT® (HPMCAS) [A-029]
Enteric coating of omeprazol granules using Shin-Etsu AQOAT® (HPMCAS) [A-031]
Enteric coating with Shin-Etsu AQOAT® (HPMCAS) by using water-ethanol solution [A-004]
Examples of aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) [A-003]
Impact of process parameters to solid dispersion particles [A-071]
Influence of alcohol on gastric resistance of Shin-Etsu AQOAT® (HPMCAS) [A-014]
IR spectrums of HPMCP and Shin-Etsu AQOAT® [H-017, A-054]
Mechanical properties of hot melt extruded amorphous solid dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-073]
Milling and downstream processing of hot melt extruded (HME) amorphous solid dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-067]
Minimum film formation temperature of Shin-Etsu AQOAT® (HPMCAS) (2) [A-047]
Minimum film formation temperature of Shin-Etsu AQOAT® (HPMCAS) [A-005]
Molecular weight of Shin-Etsu AQOAT® (HPMCAS) [A-007]
Nifedipine solid dispersion using Shin-Etsu AQOAT® - preparation by HME and downstream processing [A-051]
Partially neutralized coating technique using Shin-Etsu AQOAT® (HPMCAS) [A-037]
Scale-up of tablet enteric coating using the partially ammonia neutralized Shin-Etsu AQOAT® (HPMCAS) dispersion [A-068]
Solid dispersions (SD) using Shin-Etsu AQOAT® (HPMCAS) by holt melt extrusion [A-018]
Solubility of Shin-Etsu AQOAT® (HPMCAS) in alkali solutions for cleaning media after coating operations [A-021]
Solubility of Shin-Etsu AQOAT® (HPMCAS) in mixed organic solvents [A-035]
Solution preparation of HPMCP and Shin-Etsu AQOAT® (HPMCAS) [H-019, A-058]
Stability of Shin-Etsu AQOAT® (HPMCAS) at high temperatures [A-010]
Taste masking coating for quinine tablets [A-061]
Taste masking coating using Shin-Etsu AQOAT® (HPMCAS) and PHARMACOAT® with controlled release [A-063, P-018]
Triacetin as an alternative plasticizer for aqueous dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-057]
Grades and applications
Application
Tablets & Pellets
Taste masking by coating with enteric polymer and pore former
Continuous Manufacturing (CM) for Oral Solid Dosage Form (OSD)
Enteric/delayed release coating
Amorphous solid dispersion (ASD)
Shin-Etsu AQOAT®
AS-LF
AS-MF
AS-HF
AS-LMP
AS-MMP
AS-HMP
AS-LG
AS-MG
AS-HG
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• Suitable / •• Very Suitable
Downstream processing of spray-dried ASD with Shin-Etsu AQOAT® as carrier polymer
Take a look at our recent publication in the International Journal of Pharmaceutics X on Downstream processing of spray-dried ASD with Shin-Etsu AQOAT® as carrier polymer! Learn about the possibilities for formulating ASDs with Shin-Etsu AQOAT® into high ASD load tablets and the benefit of using L-HPC as binder and disintegrant. A great job from our technical laboratories!
Downstream processing of spray-dried ASD with Shin-Etsu AQOAT® as carrier polymer
(Quelle: International Journal of Pharmaceutics X)
Shin-Etsu AQOAT® – Benefits and Information
Hypromellose acetate succinate (HPMCAS, NF, JP, EP) was developed by Shin-Etsu in 1980s as an enteric coating polymer under the brand name Shin-Etsu AQOAT®.
The enteric coating was developed in the 1940s to act as a barrier to protect drugs with low acidic stability from degradation by gastric acid or to protect gastric mucosa from irritating drugs. Moreover, it allows to deliver drugs optimally absorbed in the small intestine in a most concentrated form in this specific region of the digestive tract.
Based on hypromellose, acetyl and succinoyl groups are introduced to the hydroxyl groups of the backbone and different pH openings are obtained by variating their amount.
The different pH in which Shin-Etsu AQOAT® is dissolving are going from 5.5 to 6.5 which is leading not only to an efficient protection of drugs from degradation by gastric acid or to protect gastric mucosa from irritating drugs as the barrier obtain is insoluble in acidic media, but also to target a drug release in different zones from the digestive tract like the duodenum, Jejenum and close to the colon.
Different grades of Shin-Etsu AQOAT®
This enteric coating polymer replies to the wish of the pharmaceutical industries to follow a more ecological pathway by reducing the used of solvents and thus their footprint.
In contrary to HPMCP (hypromellose phthalate USP/NF, JP, EP), which can only be used in organic based processes , HPMCAS can be used either in organic or water based enteric coating formulations.
Currently six grades of HPMCAS are commercially available for enteric coating. There are two physical grades having different particle size, and for each physical grade, there are three chemical grades.
Grade
Acetyl [%]
Succinoyl [%]
Opening pH value
AS-LF/LG
5-9
14-18
> 5.5
AS-MF/MG
7-11
10-14
> 6.0
AS-HF/HG
10-14
4-8
> 6.5
The two physical grades include granular grade (“G”-grade, which are the grade code ending with G. Mean particle size: approximately 0.5 mm) and fine grade (“F”-grade, which are the grade code ending with “F”. Mean particle size: approximately 5 μm). The F-grade was originally developed for aqueous dispersion coating and G-grade was designed for dissolving the polymer into organic solvents.
Over the year, several aqueous based formulations were developed by Shin-Etsu to support customers in their developments of enteric coated tablets or capsules. The detailed explanation for the preparation of Shin-Etsu AQOAT® coating dispersions can be found in our YouTube videos:
Shin-Etsu AQOAT® Aqueous Coating Dispersion with Triacetin
Shin-Etsu AQOAT® (hypromellose acetate succinate or HPMCAS) is an excellent polymer for enteric coating of solid dosage forms (tablets, pellets, capsules).
Since the introduction of HPMCAS for enteric coating by Shin-Etsu in the 1980s, the aqueous coating formulation has been continuously improved. Here we present the method of aqueous coating dispersion with triacetin using F grade.
Shin Etsu AQOAT® Enteric coating formulation fully neutralized with ammonia
In order to avoid surfactants and plasticizers, HPMCAS can be fully neutralized so that it dissolves in water resulting in a clear solution. Ammonia has been found to be the best neutralizing agent as it can be removed during the drying step.
Since the introduction of HPMCAS for enteric coating by Shin-Etsu in the 1980s, the aqueous coating formulation has been continuously improved.
Shin-Etsu AQOAT® Enteric coating formulation partly neutralized with ammonia
The partly neutralisation of the HPMCAS based on ammonia was developed in our laboratory in 2013.
Faster spray rate can be achieved due to the low viscosity and high polymer load of the obtained suspension. As a result, the process time is shorter.
Since the introduction of HPMCAS for enteric coating by Shin-Etsu in the 1980s, the aqueous coating formulation was continuously improved.
The L-Arginine partly neutralized aqueous coating formulation combines an easy, user friendly preparation method with a high polymer load in the coating suspension. The result is a shorter process time. We are glad showing and guiding you for the preparation of the coating dispersion based on L-Arginine.
Shin-Etsu AQOAT® Solvent Based Coating
Shin-Etsu AQOAT® (hypromellose acetate succinate or HPMCAS) is an excellent polymer for enteric coating of solid dosage forms (tablets, pellets, capsules).
Beside the aqueous coating formulations, HPMCAS can also be used in organic formulations as it dissolves in several organic solvents.
Leading polymer in amorphous solid dispersion
Shin-Etsu AQOAT® is a leading polymer in amorphous solid dispersion. It is suitable for spray-drying, hot melt extrusion, co-precipitation and other techniques.
Recently, Shin-Etsu developed a new physical HPMCAS grade designed for the hot melt extrusion technology having a particle size suitable for fast extrusion processes and excellent blend homogeneity under the Name Shin-Etsu AQOAT® medium particle size grade (ending code: “MP” with a mean particle size around 70-300 µm).
Get to learn more about our products and applications
In 2021, Shin-Etsu organized three online seminars where the latest developments in the fields of amorphous solid dispersion (ASD) were discussed. These webinars were focus on the equipment and process, as well as on the key excipient Hypromellose Acetate Succinate (Shin-Etsu AQOAT®, HPMCAS) linked to the most popular technologies:
Hot Melt Extrusion (HME)
Spray Drying
Downstream Processing of Spray Dried ASDs
The partner companies Shin‑Etsu, Leistritz, ProCepT, Alexanderwerk as well as invited speakers presented important insights into ASD technology. These webinars are now available on-demand here.
The Shin-Etsu team is supporting in all technical, quality and regulatory related questions related to enteric coating polymers. Our team of sales and technical sales manager can help you to develop your products, or provide support during issues at your manufacturing process. Shin-Etsu has long year experience in cellulose ether business and is aiming to give you the best possible guidance and high quality products manufactured in Japan and Germany.
Technical information about Shin-Etsu AQOAT®
Shin-Etsu has more than 70 Technical documents available for Shin-Etsu AQOAT®; such as:
Enteric Coating by different methods
Enteric Coating of Pellets/Granules
Enteric Coating of Hard Capsules/Soft Capsules
Enteric Coating of Mini-TabletsScale-up of Tablet
Enteric Coating Shin-Etsu AQOAT® DispersionApplication of Shin-Etsu AQOAT® as a carrier in solid dispersion
HME with Shin-Etsu AQOAT® and Downstream Processing
Tablet preparation of spray dried solid dispersion by roller compactor
3D Printing Tablets with Shin-Etsu AQOAT® Influence of different process parameter in Spray Drying on preparation of ASD particles
